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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

《结构与土木工程前沿（英文）》 2011年 第5卷 第3期   页码 315-322 doi: 10.1007/s11709-011-0117-7

摘要： Load and resistance factors are generally obtained using the first order reliability method (FORM) in which the design point should be determined and derivative-based iterations used. In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormal) distribution, is investigated. A simple method based on the third-moment method for estimating load and resistance factors is then proposed, and a simple formula for the target mean resistance is also presented to avoid iterative computations. Unlike the currently used method, the proposed method can be used to determine load and resistance factors, even when the probability density functions (PDFs) of the basic random variables are not available. Moreover, the proposed method does not require the iterative computation of derivatives or any design points. Thus, the method provides a more convenient and effective way to estimate load and resistance factors in practical engineering applications. Numerical examples are presented to demonstrate the advantages of the proposed third moment method for determining load and resistance factors.

关键词： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution     target mean resistance     simple formula    

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Damage identification in connections of moment frames using time domain responses and an optimizationmethod

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 851-866 doi: 10.1007/s11709-021-0739-3

摘要： Damage is defined as changes to the material and/or geometric properties of a structural system, comprising changes to the boundary conditions and system connectivity, adversely affecting the system’s performance. Inspecting the elements of structures, particularly critical components, is vital to evaluate the structural lifespan and safety. In this study, an optimization-based method for joint damage identification of moment frames using the time-domain responses is introduced. The beam-to-column connection in a metallic moment frame structure is modeled by a zero-length rotational spring at both ends of the beam element. For each connection, an end-fixity factor is specified, which changes between 0 and 1. Then, the problem of joint damage identification is converted to a standard optimization problem. An objective function is defined using the nodal point accelerations extracted from the damaged structure and an analytical model of the structure in which the nodal accelerations are obtained using the Newmark procedure. The optimization problem is solved by an improved differential evolution algorithm (IDEA) for identifying the location and severity of the damage. To assess the capability of the proposed method, two numerical examples via different damage scenarios are considered. Then, a comparison between the proposed method and the existing damage identification method is provided. The outcomes reveal the high efficiency of the proposed method for finding the severity and location of joint damage considering noise effects.

关键词： damage identification     beam-to-column connection     time-domain response     optimization    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 383-388 doi: 10.1007/s11684-016-0488-1

摘要：

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

关键词： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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工程结构可靠性分析的高阶矩法研究

宫凤强,李夕兵,邓建

《中国工程科学》 2006年 第8卷 第5期   页码 69-73

摘要：

提出了工程结构可靠性分析的高阶矩方法。主要是基于数值逼近原理，以切比雪夫正交函数族{Tk(x)}做基，利用功能函数的高阶矩信息，通过计算功能函数概率密度函数的逼近表达式，然后根据工程结构可靠性的一般表达式来计算结构的失效概率，进行可靠性分析。通过经典分布函数的数值检验和结构构件失效概率的计算结果比较，表明了该方法在理论上的正确性和工程中的实用性。

关键词： 结构可靠性     高阶矩     切比雪夫多项式     失效概率    

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Instantaneous deflection of light-weight concrete slabs

Behnam VAKHSHOURI, Shami NEJADI

《结构与土木工程前沿（英文）》 2017年 第11卷 第4期   页码 412-423 doi: 10.1007/s11709-017-0416-8

摘要： Construction loading before the age of 28 d can have the most significant effects on the slabs, especially for multi-story structures. The changing properties of the young concrete complicate the prediction of serviceability design requirements also. An experimental investigation is performed on four simply supported Light-Weight Concrete (LWC) one-way slabs subjected to immediate loading at 14 d. Effects of aggregate type, loading levels and cracking moment together with the influences of ultimate moment capacity and service moment on the instantaneous deflection of slabs are studied. Comparison of the obtained results with predictions of existing models in the literature shows considerable differences between the recorded and estimated instantaneous deflection of LWC slabs. Based on sensitivity analysis of the effective parameters, a new equation is proposed and verified to predict the instantaneous deflection of LWC slabs subjected to loading at the age of 14 d.

关键词： instantaneous deflection     light-weight concrete     expanded polystyrene     effective moment of inertia     cracking moment     moment capacity     service moment    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

《医学前沿（英文）》 2022年 第16卷 第5期   页码 701-713 doi: 10.1007/s11684-022-0951-0

摘要： A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal response duration or treatment remission. Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatment. Evasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer therapy. It has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs, particularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired resistance. Hence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Estimating moment capacity of ferrocement members using self-evolving network

Abdussamad ISMAIL

《结构与土木工程前沿（英文）》 2019年 第13卷 第4期   页码 926-936 doi: 10.1007/s11709-019-0527-5

摘要： In this paper, an empirical model based on self-evolving neural network is proposed for predicting the flexural behavior of ferrocement elements. The model is meant to serve as a simple but reliable tool for estimating the moment capacity of ferrocement members. The proposed model is trained and validated using experimental data obtained from the literature. The data consists of information regarding flexural tests on ferrocement specimens which include moment capacity and cross-sectional dimensions of specimens, concrete cube compressive strength, tensile strength and volume fraction of wire mesh. Comparisons of predictions of the proposed models with experimental data indicated that the models are capable of accurately estimating the moment capacity of ferrocement members. The proposed models also make better predictions compared to methods such as the plastic analysis method and the mechanism approach. Further comparisons with other data mining techniques including the back-propagation network, the adaptive spline, and the Kriging regression models indicated that the proposed models are superior in terms prediction accuracy despite being much simpler models. The performance of the proposed models was also found to be comparable to the GEP-based surrogate model.

关键词： ferrocement     moment capacity     self-evolving neural network    

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Shaking-moment balancing of mechanisms with principal vectors and momentum

V. van der WIJK

《机械工程前沿（英文）》 2013年 第8卷 第1期   页码 10-16 doi: 10.1007/s11465-013-0359-2

摘要：

The design of shaking-moment-balanced linkages still is challenging. Considering moment balance in the very beginning of the design process of mechanisms is important for finding applicable solutions. For this purpose, the method of principal vectors is investigated, showing a compact notation of the angular momentum with respect to the center of mass. The moment balance conditions are derived for three elements in series from which balance solutions are synthesized and illustrated. From the application for moment balancing of a 4R four-bar linkage it is shown that the moment balancing of closed kinematic chains remains challenging.

关键词： shaking-moment balancing     principal vector linkage     angular momentum    

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Initial stiffness and moment resistance of reinforced joint with end-plate connection

Sufang WANG, Yiyi CHEN,

《结构与土木工程前沿（英文）》 2009年 第3卷 第4期   页码 345-351 doi: 10.1007/s11709-009-0054-x

摘要： In beam-to-column joint with bolted end-plate connection, the structural details of column flange reinforced by backing plate and column web panel reinforced by supplementary plate are analyzed. The joint is divided into some basic components, and the initial stiffness of each component is obtained. Especially, the initial stiffness of reinforced components is drawn by theoretical model and finite element analysis. The initial stiffness of reinforced joint can be obtained by assembling the initial stiffness of each component. The design moment resistance of column flange reinforced by backing plate is deduced based on yield line method, and the design moment resistances of other components are deduced based on present codes. The design moment resistance of the reinforced joint is then determined by the minimum of the design moment resistances of all components. By comparison with the results of finite element calculation, it is verified that the method to calculate the initial stiffness of reinforced joint is accurate enough to be used to estimate the rigid behavior of the joint and to make parametric study.

关键词： steel structure     end-plate connection     backing plate     supplementary web plate     initial stiffness     moment resistance    

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Shallow foundation response variability due to soil and model parameter uncertainty

Prishati RAYCHOWDHURY,Sumit JINDAL

《结构与土木工程前沿（英文）》 2014年 第8卷 第3期   页码 237-251 doi: 10.1007/s11709-014-0242-1

摘要： Geotechnical uncertainties may play crucial role in response prediction of a structure with substantial soil-foundation-structure-interaction (SFSI) effects. Since the behavior of a soil-foundation system may significantly alter the response of the structure supported by it, and consequently several design decisions, it is extremely important to identify and characterize the relevant parameters. Moreover, the modeling approach and the parameters required for the modeling are also critically important for the response prediction. The present work intends to investigate the effect of soil and model parameter uncertainty on the response of shallow foundation-structure systems resting on dry dense sand. The SFSI is modeled using a beam-on-nonlinear-winkler-foundation (BNWF) concept, where soil beneath the foundation is assumed to be an assembly of discrete, nonlinear elements composed of springs, dashpots and gap elements. The sensitivity of both soil and model input parameters on shallow foundation responses are investigated using first-order second-moment (FOSM) analysis and Monte Carlo simulation through Latin hypercube sampling technique. It has been observed that the degree of accuracy in predicting the responses of the shallow foundation is highly sensitive soil parameters, such as friction angle, Poisson’s ratio and shear modulus, rather than model parameters, such as stiffness intensity ratio and spring spacing; indicating the importance of proper characterization of soil parameters for reliable soil-foundation response analysis.

关键词： shallow foun dation     sensitivity analysis     centrifuge data     first-order-second-moment (FOSM) method     parameter uncertainty    

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Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1584-1594 doi: 10.1007/s11705-022-2189-4

摘要： The separation of rare earth elements is particularly difficult due to their similar physicochemical properties. Based on the tiny differences of ionic radius, solvent extraction has been developed as the “mass method” in industry with hundreds of stages, extremely intensive chemical consumption and large capital investments. The differences of the ionic magnetic moment among rare earths are greater than that of ionic radius. Herein, a novel method based on the large ionic magnetic moment differences of rare earth elements was proposed to promote the separation efficiency. Rare earths were firstly dissolved in the ionic liquid, then the ordering degree of them was improved with the Z-bond effect, and finally the magnetic moment differences between paramagnetic and diamagnetic rare earths in quasi-liquid system were enhanced. Taking the separation of Er/Y, Ho/Y and Er/Ho as examples, the results showed that Er(III) and Ho(III) containing ionic liquids had obvious magnetic response, while ionic liquids containing Y(III) had no response. The separation factors of Er/Y and Ho/Y were achieved at 9.0 and 28.82, respectively. Magnetic separation via quasi-liquid system strategy provides a possibility of the novel, green, and efficient method for rare earth separation.

关键词： rare earth element     different magnetic moment     magnetic separation     ionic liquid    

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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

《机械工程前沿（英文）》 2011年 第6卷 第4期   页码 409-418 doi: 10.1007/s11465-011-0245-8

摘要：

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order shear deformation theory (TSDT) is studied. The beam is made of laminated composite, and located on a Pasternak viscoelastic foundation. By using the principle of total minimum potential energy, the governing partial differential equations of motion are obtained. The solution is directed to compute the deflection and bending moment distribution along the length of the beam. Also, the effects of two types of composite materials, stiffness and shear layer viscosity coefficients of foundation, velocity and frequency of the moving load over the beam response are studied. In order to demonstrate the accuracy of the present method, the results TSDT are compared with the previously obtained results based on first-order shear deformation theory, with which good agreements are observed.

关键词： timoshenko composite beam     pasternak viscoelastic foundation     third-order shear deformation theory (TSDT)     harmonic moving load    

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Improved prediction of pile bending moment and deflection due to adjacent braced excavation

《结构与土木工程前沿（英文）》 doi: 10.1007/s11709-023-0961-2

摘要： Deep excavations in dense urban areas have caused damage to nearby existing structures in numerous past construction cases. Proper assessment is crucial in the initial design stages. This study develops equations to predict the existing pile bending moment and deflection produced by adjacent braced excavations. Influential parameters (i.e., the excavation geometry, diaphragm wall thickness, pile geometry, strength and small-strain stiffness of the soil, and soft clay thickness) were considered and employed in the developed equations. It is practically unfeasible to obtain measurement data; hence, artificial data for the bending moment and deflection of existing piles were produced from well-calibrated numerical analyses of hypothetical cases, using the three-dimensional finite element method. The developed equations were established through a multiple linear regression analysis of the artificial data, using the transformation technique. In addition, the three-dimensional nature of the excavation work was characterized by considering the excavation corner effect, using the plane strain ratio parameter. The estimation results of the developed equations can provide satisfactory pile bending moment and deflection data and are more accurate than those found in previous studies.

关键词： pile responses     excavation     prediction     deflection     bending moments    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

《医学前沿（英文）》 2022年 第16卷 第1期   页码 93-101 doi: 10.1007/s11684-021-0914-x

摘要： Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19). It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time, which calls for an additional vaccination regime, as known as booster immunization, to restore immunity among previously vaccinated populations. Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccine (Vero cell), on 136 participants aged between 18 to 63 years. Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28. While systemic reactogenicity was either absent or mild, SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose immunization regime. Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination. Furthermore, in an exploratory study, a newly developed recombinant protein vaccine, NVSI-06-08 (CHO Cells), was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals. Together, these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity, providing support for further trials of booster vaccination in larger populations.

关键词： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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High-order moment methods for LRFD including random variables with unknown probability distributions

Zhao-Hui LU, Yan-Gang ZHAO, Zhi-Wu YU

《结构与土木工程前沿（英文）》 2013年 第7卷 第3期   页码 288-295 doi: 10.1007/s11709-013-0210-1

摘要： The reliability-based load and resistance factors design (LRFD) has been widely used in the structural design codes. In almost all of the current reliability methods for the determination of the load and resistance factors, the basic random variables are assumed to have known probability distributions. However, in reality, the probability distributions of some of the basic random variables are often unknown due to the lack of statistical data. In this paper, the high-order moment methods for LRFD including random variables with unknown probability distributions are proposed. From the investigation of the present paper, it can be concluded that: 1) The load and resistance factors can be determined even when the probability distributions of the basic random variables are unknown; 2) The present method is convenient and more effective in estimating the load and resistance factors in practical engineering since it needs neither the iterative computation of derivatives nor any design points; 3) In the applicable range of the high-order moment method, although the load and resistance factors obtained by the proposed method may be different from those obtained by first order reliability method (FORM), the target mean resistances obtained by both methods are essentially the same.

关键词： high-order moment methods     applicable range     load and resistance factors     target mean resistance    

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标题 作者 时间 类型 操作

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

期刊论文

Damage identification in connections of moment frames using time domain responses and an optimizationmethod

期刊论文

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

期刊论文

工程结构可靠性分析的高阶矩法研究

宫凤强,李夕兵,邓建

期刊论文

Instantaneous deflection of light-weight concrete slabs

Behnam VAKHSHOURI, Shami NEJADI

期刊论文

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

期刊论文

Estimating moment capacity of ferrocement members using self-evolving network

Abdussamad ISMAIL

期刊论文

Shaking-moment balancing of mechanisms with principal vectors and momentum

V. van der WIJK

期刊论文

Initial stiffness and moment resistance of reinforced joint with end-plate connection

Sufang WANG, Yiyi CHEN,

期刊论文

Shallow foundation response variability due to soil and model parameter uncertainty

Prishati RAYCHOWDHURY,Sumit JINDAL

期刊论文

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

期刊论文

Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

期刊论文

Improved prediction of pile bending moment and deflection due to adjacent braced excavation

期刊论文

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

期刊论文

High-order moment methods for LRFD including random variables with unknown probability distributions

Zhao-Hui LU, Yan-Gang ZHAO, Zhi-Wu YU

期刊论文